Question

Match List - I with List - II.

List - I	List - II
A. Epidermal growth factor (EGF)	I. Monocyte
B. Platelet derived growth factor (PDGF)	II. Salivary gland, fibroblast
C. Transforming growth factor (TGF-\(\alpha\))	III. Platelet
D. Tumor necrosis factor (TNF-\(\alpha\))	IV. Epithelial cells

Choose the correct answer from the options given below:

• A. A-I, B-II, C-III, D-IV \
• B. A-IV, B-III, C-II, D-I \
• C. A-II, B-III, C-IV, D-I \
• D. A-I, B-II, C-IV, D-III

Hint:

"Platelet-derived" explicitly gives away its source: it is produced by platelets (B-III). This clue helps quickly identify the correct matching choice.

Answer 1

The Correct Option is C

Step 1: Concept Growth factors and cytokines are signaling proteins secreted by specific cell types or glands to regulate cellular growth, proliferation, and immune responses.

Step 2: Meaning Matching each signaling protein with its primary source or target cell type.

Step 3: Analysis * Epidermal growth factor (EGF) (A) is famously secreted by the submandibular salivary glands and acts on fibroblasts and epithelial tissues $\rightarrow$ (A-II). * Platelet-derived growth factor (PDGF) (B) is stored in the $\alpha$-granules of blood platelets and released during clotting to stimulate wound healing $\rightarrow$ (B-III). * Transforming growth factor $\alpha$ (TGF-$\alpha$) (C) is produced by epithelial cells, keratinocytes, and macrophages, binding to the EGF receptor to stimulate epithelial cell proliferation $\rightarrow$ (C-IV). * Tumor necrosis factor $\alpha$ (TNF-$\alpha$) (D) is a pro-inflammatory cytokine primarily produced and secreted by activated monocytes and macrophages $\rightarrow$ (D-I).

Step 4: Conclusion The resulting matching sequence is A-II, B-III, C-IV, D-I, which matches option C. Final Answer: (C)