Question

Match List - I with List - II.

List - I	List - II
A. 6-mercaptopurine	I. Monoclonal antibody
B. Mitomycin	II. Platinum compound
C. Cisplatin	III. Antibiotic
D. Imatinib	IV. Purine analogue

Choose the correct answer from the options given below:

• A. A-IV, B-II, C-I, D-III \
• B. A-IV, B-III, C-II, D-I \
• C. A-III, B-I, C-II, D-IV \
• D. A-III, B-I, C-IV, D-II

Hint:

"Cisplatin" has "platin" directly in its name, making it an easy match for a platinum compound (C-II).

Answer 1

The Correct Option is B

Step 1: Concept Cancer chemotherapeutic agents are classified based on their chemical structures, molecular targets, and mechanisms of action.

Step 2: Meaning * Antimetabolites masquerade as normal nucleotides. * Alkylating agents or cross-linkers physically damage DNA. * Targeted therapies specifically block malfunctioning cellular signaling pathways or proteins.

Step 3: Analysis * 6-mercaptopurine (A) acts as an antimetabolite that blocks purine nucleotide synthesis by mimicking normal purines $\rightarrow$ (A-IV). * Mitomycin (B) is a potent antitumor antibiotic isolated from Streptomyces species that acts as a DNA cross-linker $\rightarrow$ (B-III). * Cisplatin (C) is a platinum-based coordination complex that binds tightly to DNA to form intra-strand cross-links $\rightarrow$ (C-II). * Imatinib (D) is a targeted small-molecule inhibitor designed to block tyrosine kinase proteins like BCR-ABL, which often shares structural classification with targeted biological pathways $\rightarrow$ (D-I).

Step 4: Conclusion The resulting unified configuration is A-IV, B-III, C-II, D-I, matching option B. Final Answer: (B)