Question

Match List-I with List-II

List-I (Name of the component) & List-II (Vitamin/Coenzyme)
(A) Pantothenic acid & (II) Coenzyme A
(B) Para-Amino Benzoic Acid (PABA) & (III) Folic acid
(C) Ribose & (I) NAD
(D) Pentanoic acid & (IV) Lipoic acid

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (II), (B) - (I), (C) - (IV), (D) - (III)
• (A) - (II), (B) - (III), (C) - (I), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Remember that Pantothenate is the direct precursor of Coenzyme A. PABA is a key structural component of Folic acid, which is why sulfa drugs (PABA analogs) inhibit bacterial folate synthesis.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Many critical coenzymes and vitamins are complex organic molecules made up of smaller constituent chemical moieties or building blocks.

Step 2: Detailed Explanation:
Let us match the chemical components in List-I with their respective coenzymes or vitamins in List-II:
- (A) Pantothenic acid $\rightarrow$ (II) Coenzyme A:
Pantothenic acid (Vitamin B5) is a water-soluble vitamin.
It is chemically integrated into the structure of Coenzyme A (CoA), which serves as an acyl group carrier in metabolism.
- (B) Para-Amino Benzoic Acid (PABA) $\rightarrow$ (III) Folic acid:
Folic acid (Vitamin B9) is composed of three building blocks: a pteridine ring, glutamic acid, and para-aminobenzoic acid (PABA).
PABA is an essential biosynthetic precursor of folate in plants and bacteria.
- (C) Ribose $\rightarrow$ (I) NAD:
Nicotinamide Adenine Dinucleotide (NAD) is a dinucleotide coenzyme.
It contains two ribose sugar units: one attached to the nicotinamide ring and the other attached to the adenine ring.
- (D) Pentanoic acid $\rightarrow$ (IV) Lipoic acid:
Lipoic acid consists of a disulfide-containing dithiolane ring attached to a 5-carbon carboxylic acid chain (pentanoic acid).
This pentanoic acid chain allows it to covalently link to lysine residues of enzyme complexes.
This results in the matching sequence: (A)-(II), (B)-(III), (C)-(I), (D)-(IV).

Step 3: Final Answer:
The correct matching sequence is (A) - (II), (B) - (III), (C) - (I), (D) - (IV).