Question

Match List-I with List-II


List-I (Compound) & List-II (Vitamin D derivative)
(A). Ergocalciferol & (I). Vitamin D2
(B). Cholecalciferol & (II). 25-Hydroxy Vitamin D3
(C). Calcidiol & (III). 1,25-Dihydroxy Vitamin D3
(D). Calcitriol & (IV). Vitamin D3


Choose the correct answer from the options given below:

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
• (A) - (I), (B) - (IV), (C) - (II), (D) - (III)
• (A) - (I), (B) - (IV), (C) - (III), (D) - (II)

Hint:

Remember that "di-ol" indicates two hydroxyl groups (calcidiol), while "tri-ol" indicates three hydroxyl groups (calcitriol, the active hormone).

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Vitamin D exists in several forms and undergoes metabolic hydroxylations in the liver and kidneys to become biologically active.

Step 2: Detailed Explanation:
Let us match each term with its correct chemical definition:
- (A) Ergocalciferol is the plant-derived form of Vitamin D, also known as Vitamin D2, so (A) matches with (I).
- (B) Cholecalciferol is the animal-derived form synthesized in the skin under UV light, known as Vitamin D3, so (B) matches with (IV).
- (C) Calcidiol is formed by hydroxylation of cholecalciferol in the liver, yielding 25-hydroxyvitamin D3, so (C) matches with (II).
- (D) Calcitriol is formed by a second hydroxylation in the kidneys, yielding the fully active hormone 1,25-dihydroxyvitamin D3, so (D) matches with (III).
This gives the correct sequence: (A)-(I), (B)-(IV), (C)-(II), (D)-(III).

Step 3: Final Answer:
Hence, the correct option is (C).