Question

Match List-I with List-II 
Choose the correct answer from the options given below:} 
 

• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (II), (D) - (I)
• (A) - (III), (B) - (I), (C) - (II), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

To remember this chemical matching:
- Digitoxin is a cardiac glycoside (related to digoxin).
- Atropine is a tropane alkaloid (nitrogen-containing plant base).
- Abrin is a toxic protein (similar to ricin).

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Veterinary toxicology and pharmacology classify plant-derived bioactive agents and toxins based on their chemical structures and functional groups.
These include glycosides, alkaloids, toxic proteins, and terpenes, each with unique systemic pathways and toxicological mechanisms.

Step 2: Detailed Explanation:
Let us analyze and match the chemical classes in List-I with their corresponding agents in List-II:
- (A) Glycoside: This matches with Digitoxin (III).
Digitoxin is a cardiotoxic steroid glycoside derived from the foxglove plant (*Digitalis purpurea*).
It acts by inhibiting the \(\text{Na}^+/\text{K}^+\)-ATPase pump, which increases intracellular calcium and enhances cardiac contractility.
- (B) Protein: This matches with Abrin (IV).
Abrin is a highly toxic, ribosome-inactivating plant protein (toxalbumin) obtained from the seeds of the rosary pea (*Abrus precatorius*).
It inhibits cellular protein synthesis, causing cell death.
- (C) Terpene: This matches with Picrotoxin (II).
Picrotoxin is a non-nitrogenous, plant-derived sesquiterpene obtained from *Anamirta cocculus*.
It acts as a potent central nervous system stimulant and convulsant by blocking \(\text{GABA}_\text{A}\)-receptor chloride channels.
- (D) Alkaloid: This matches with Atropine (I).
Atropine is a classic tropane alkaloid derived from *Atropa belladonna*.
It acts as a competitive antagonist at muscarinic acetylcholine receptors.
This matching sequence gives: (A) - (III), (B) - (IV), (C) - (II), (D) - (I).

Step 3: Final Answer:
The correct match is (A) - (III), (B) - (IV), (C) - (II), (D) - (I). This corresponds to option (B).