Question

Match List-I with List-II: 

List I (Class of drug)	List II (Drug name)
(A) Prostaglandin analogue	(I) Calcium carbonate
(B) Promotility agent	(II) Bethanechol
(C) Antacid	(III) Misoprostol
(D) \( \mathrm{H_2} \) antagonist	(IV) Ranitidine

Choose the correct answer from the options given below:

• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (III), (B) - (I), (C) - (II), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

To remember this quickly: ranitidine is a well-known $H_2$-blocker (D-IV), and misoprostol is a classic prostaglandin cytoprotective drug (A-III).

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
This matching question requires associating different therapeutic classes of gastrointestinal drugs with their specific pharmacological agents.

Step 2: Detailed Explanation:
Let us analyze each class of drug and its corresponding agent:
- Prostaglandin analogue (A): Misoprostol is a synthetic prostaglandin $E_1$ ($PGE_1$) analogue. It is used to prevent gastric ulcers, particularly those induced by NSAIDs, by decreasing gastric acid secretion and enhancing mucosal cytoprotection. This matches with (III).
- Promotility agent (B): Bethanechol is a cholinergic (muscarinic) agonist that stimulates gastrointestinal smooth muscle contractility, thereby acting as a prokinetic or promotility agent. This matches with (II).
- Antacid (C): Calcium carbonate is a systemic/non-systemic inorganic compound used to chemically neutralize gastric acid in the stomach. This matches with (I).
- $H_2$ antagonist (D): Ranitidine is a competitive antagonist of histamine at the $H_2$ receptors on gastric parietal cells, thereby inhibiting gastric acid secretion. This matches with (IV).
Combining these individual linkages, the matching sequence is (A) - (III), (B) - (II), (C) - (I), (D) - (IV).

Step 3: Final Answer:
The matching sequence is represented by option (A).