Question

Match List-I with List-II

List-I (Name of drugs)	List-II (Characteristics)
(A) Saline	(I) Surface active agent
(B) Propylene glycol	(II) Mucolytic agent
(C) Bromohexin	(III) Diluent mucokinetic agent
(D) Iodide	(IV) Bronchomucotropic agent

• (A) - (II), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (IV), (B) - (II), (C) - (I), (D) - (III)
• (A) - (III), (B) - (I), (C) - (II), (D) - (IV)

Hint:

To remember respiratory drug classes:
- Bromhexine \(\rightarrow\) Mucolytic (chemically dissolves/lyses mucus).
- Saline \(\rightarrow\) Diluent (dilutes and hydrates mucus).
- Iodide \(\rightarrow\) Bronchomucotropic (stimulates watery secretions).

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Expectorants and mucolytics are drugs used to modify the physical properties of respiratory tract secretions, making them easier for the animal to clear via coughing.
These drugs are classified based on their primary physiological mechanisms of action.

Step 2: Detailed Explanation:
Let us analyze each of the drug-characteristic pairs:
- (A) Saline (Normal/Hypertonic Saline): Saline solutions, when administered as aerosols or nebulizers, act as diluent mucokinetic agents.
They draw water into the airway lumen by osmosis, directly hydrating the viscous respiratory secretions and reducing their thickness, making them easier to clear.
Thus, (A) matches with (III).
- (B) Propylene glycol: This compound acts as a surface-active agent.
It reduces the surface tension of respiratory tract fluids, helping to disperse and dissolve tenacious mucus plugs and foam.
Thus, (B) matches with (I).
- (C) Bromhexine (spelled "Bromohexin" in the question): Bromhexine is a classic mucolytic agent.
It acts by depolymerizing mucopolysaccharide fibers within the mucus, directly breaking down the chemical bonds that give mucus its high viscosity.
Thus, (C) matches with (II).
- (D) Iodide (e.g., Potassium Iodide): Iodides are classified as bronchomucotropic agents (or secretomotor expectorants).
When administered orally, they are absorbed and secreted by the bronchial glands, directly stimulating them to produce a thin, watery secretion.
They also irritate the gastric mucosa, triggering a vagal reflex that further increases airway secretions.
Thus, (D) matches with (IV).
Therefore, the correct matching is: (A) - (III), (B) - (I), (C) - (II), (D) - (IV).

Step 3: Final Answer:
The correct option is (D).