Question

Match List I (Nutrient excess or deficiency) with List II (Clinical effects) and select the correct answer using the codes given below the lists.

List I (Nutrient excess or deficiency)	List II (Clinical effects)
A. Copper	1. Eczematous dermatitis around nose and mouth
B. Iron	2. Diabetes mellitus
C. Zinc	3. Increased density of bone
D. Fluoride	4. Chronic liver disease

• A. A-4, B-2, C-1, D-3
• B. A-3, B-2, C-1, D-4
• C. A-4, B-1, C-2, D-3
• D. A-3, B-1, C-2, D-4

Hint:

Think of Wilson's disease and hemochromatosis for the metal-organ links.

Answer 1

The Correct Option is A

Step 1: Understanding the Question:
We must match each nutrient (copper, iron, zinc, fluoride) to the clinical effect linked to its excess or deficiency, and then pick the code combination that matches correctly.

Step 2: Key Formula or Approach:
Recall the classic disease caused by each of these four substances when present in excess (or, for zinc, when deficient), then line each one up with the listed clinical effect.

Step 3: Detailed Explanation:
Copper excess accumulates in the liver, brain and cornea, as seen in Wilson's disease, and this leads to chronic liver disease, so Copper matches item 4. Iron excess, as seen in hereditary hemochromatosis, deposits in the pancreas and other organs, damaging the insulin producing cells and causing what is classically called bronze diabetes, so Iron matches item 2, diabetes mellitus. Zinc deficiency causes a condition called acrodermatitis enteropathica, with eczema like skin lesions around the mouth, nose and other body openings, along with hair loss and diarrhea, so Zinc matches item 1, eczematous dermatitis around the nose and mouth. Excess fluoride intake over a long period causes skeletal fluorosis, in which extra fluoride is laid down in bone, making the bone denser (and, at the same time, more brittle), so Fluoride matches item 3, increased density of bone. Putting this together, A-4, B-2, C-1, D-3 is the correct set of matches.

Step 4: Final Answer:
The correct code is A-4, B-2, C-1, D-3, option (a).