Question

Macrocarriers differ from microcarriers in that they

• A. Are smaller in size
• B. Provide structured growth surfaces
• C. Are used only for bacteria
• D. Prevent cell attachment

Hint:

Remember: \[ \boxed{\text{Microcarrier}=\text{Small Suspended Beads}} \] \[ \boxed{\text{Macrocarrier}=\text{Large Structured Surface}} \] Both systems support anchorage-dependent animal cells, but macrocarriers provide fixed growth surfaces.

Answer 1

The Correct Option is B

Concept: Macrocarriers are large support materials used for the cultivation of anchorage-dependent animal cells. Unlike microcarriers, which are tiny beads suspended in culture medium, macrocarriers provide fixed, structured surfaces that allow cells to attach and grow in an organized manner.

Step 1: Understand macrocarriers.
Macrocarriers are available in the form of:
• Plates
• Fibres
• Membranes
• Porous scaffolds These structures provide a large surface area for cell attachment.

Step 2: Comparison with microcarriers.
Microcarriers:
• Small spherical beads
• Suspended in stirred bioreactors
• Suitable for large-scale production Macrocarriers:
• Larger support structures
• Fixed inside the culture vessel
• Provide organized growth surfaces
• Facilitate easier observation and harvesting

Step 3: Eliminate incorrect options.

• Macrocarriers are larger, not smaller.
• They are used for animal cells rather than bacteria.
• They promote, rather than prevent, cell attachment.
• Their defining feature is the structured growth surface. Final Answer: \[ \boxed{Option (B) is correct \]