Question

Leptin is a hormone produced by fat cells associated with regulation of energy intake and expenditure. Low levels of leptin hormones have been specifically reported in patients suffering from a characteristic psychological disorder. That disorder is:

• A. Alzheimer's Disease
• B. Obsessive Compulsive Disorder
• C. Manic Personality Disorder
• D. Anorexia Nervosa

Hint:

Leptin ∝ Body fat Low fat (Anorexia) → Low leptin

Answer 1

The Correct Option is D

Concept:
Leptin is a hormone secreted by adipose (fat) tissue and plays a key role in:
• Regulating appetite
• Controlling energy balance
• Signaling satiety to the hypothalamus

Step 1: Understanding leptin function.
Leptin levels are directly proportional to body fat:
• More fat → high leptin
• Less fat → low leptin

Step 2: Understanding anorexia nervosa.
Anorexia nervosa is a psychological disorder characterized by:
• Extreme restriction of food intake
• Significant weight loss
• Low body fat

Step 3: Linking leptin and anorexia.
Due to reduced fat stores:
• Leptin production decreases significantly

Step 4: Evaluating options.

• Alzheimer's disease → neurodegenerative, unrelated to leptin levels
• OCD → anxiety disorder, no direct leptin link
• Manic personality disorder → mood disorder
• Anorexia nervosa → low body fat → low leptin (correct)

Step 5: Clinical implication.
Low leptin levels may:
• Disrupt hormonal balance
• Affect menstrual cycles
• Alter metabolic processes

Step 6: Conclusion.
Thus, the disorder associated with low leptin is: \[ \boxed{\text{Anorexia Nervosa}} \]