Question:
Interstitial nephritis is common with
Interstitial nephritis is common with
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Think of the drug class notorious for allergic tubulointerstitial injury, not pigment-induced ATN.
Updated On: Jun 24, 2026
- NSAID
- Black water fever
- Rhabdomyolysis
- Tumor lysis syndrome
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The Correct Option is A
Solution and Explanation
Step 1: Acute interstitial nephritis (AIN) is an immune-mediated, allergic injury of the renal interstitium and tubules. Drugs are by far the commonest cause, accounting for the majority of cases.
Step 2: Among the listed options, NSAIDs are a classic and very common cause of drug-induced interstitial nephritis. Other frequent culprits include beta-lactam antibiotics (penicillins, cephalosporins), sulfonamides, rifampicin, quinolones, allopurinol, diuretics (thiazides, furosemide), proton pump inhibitors like omeprazole, and H2 blockers.
Step 3: Why the other options are wrong - Blackwater fever (severe falciparum malaria), rhabdomyolysis and tumor lysis syndrome all damage the kidney chiefly by pigment or crystal/urate load causing acute tubular necrosis or tubular obstruction, not a primary allergic interstitial nephritis.
Step 4: Hence the answer is NSAID.
Step 2: Among the listed options, NSAIDs are a classic and very common cause of drug-induced interstitial nephritis. Other frequent culprits include beta-lactam antibiotics (penicillins, cephalosporins), sulfonamides, rifampicin, quinolones, allopurinol, diuretics (thiazides, furosemide), proton pump inhibitors like omeprazole, and H2 blockers.
Step 3: Why the other options are wrong - Blackwater fever (severe falciparum malaria), rhabdomyolysis and tumor lysis syndrome all damage the kidney chiefly by pigment or crystal/urate load causing acute tubular necrosis or tubular obstruction, not a primary allergic interstitial nephritis.
Step 4: Hence the answer is NSAID.
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