Question:
All of the following drugs may cause hirsutism, except:
All of the following drugs may cause hirsutism, except:
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One drug is an antiandrogen used to treat the very condition.
Updated On: Jun 24, 2026
- Danazol
- Phenytoin
- Norethisterone
- Flutamide
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The Correct Option is D
Solution and Explanation
Step 1: Hirsutism is excess male-pattern hair in women, driven mainly by androgenic stimulation of hair follicles.
Step 2: Danazol is a synthetic androgen with strong androgenic and anabolic activity, so it commonly causes hirsutism. Option A causes it.
Step 3: Phenytoin is a well-known cause of hypertrichosis and hirsutism, alongside gum hyperplasia and coarsening of features. Option B causes it.
Step 4: Norethisterone is a 19-nortestosterone derived progestin with residual androgenic activity, so it can produce hirsutism and acne. Option C causes it.
Step 5: Flutamide is a non-steroidal ANTI-androgen. It blocks androgen receptors and is actually used to TREAT hirsutism, not cause it. So option D is the exception.
Conclusion: The drug that does not cause hirsutism is flutamide, option D.
Step 2: Danazol is a synthetic androgen with strong androgenic and anabolic activity, so it commonly causes hirsutism. Option A causes it.
Step 3: Phenytoin is a well-known cause of hypertrichosis and hirsutism, alongside gum hyperplasia and coarsening of features. Option B causes it.
Step 4: Norethisterone is a 19-nortestosterone derived progestin with residual androgenic activity, so it can produce hirsutism and acne. Option C causes it.
Step 5: Flutamide is a non-steroidal ANTI-androgen. It blocks androgen receptors and is actually used to TREAT hirsutism, not cause it. So option D is the exception.
Conclusion: The drug that does not cause hirsutism is flutamide, option D.
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