Step 1: Take the sides proportional to the given ratio.
Let
\[
a=4k,\quad b=5k,\quad c=6k
\]
The semi-perimeter is
\[
s=\frac{4k+5k+6k}{2}
=\frac{15k}{2}
\]
Step 2: Find the area using Heron's formula.
Using
\[
\Delta=\sqrt{s(s-a)(s-b)(s-c)}
\]
we get
\[
\Delta=
\sqrt{\frac{15k}{2}\cdot\frac{7k}{2}\cdot\frac{5k}{2}\cdot\frac{3k}{2}}
\]
\[
=\frac{k^2}{4}\sqrt{15\cdot7\cdot5\cdot3}
\]
\[
=\frac{15\sqrt7}{4}k^2
\]
Step 3: Find the inradius \(r\).
We know
\[
\Delta=rs
\]
Hence
\[
r=\frac{\Delta}{s}
=\frac{\frac{15\sqrt7}{4}k^2}{\frac{15k}{2}}
\]
\[
r=\frac{\sqrt7}{2}k
\]
Step 4: Find the circumradius \(R\).
Using
\[
\Delta=\frac{abc}{4R}
\]
\[
R=\frac{abc}{4\Delta}
\]
Substituting,
\[
R=\frac{(4k)(5k)(6k)}
{4\left(\frac{15\sqrt7}{4}k^2\right)}
\]
\[
R=\frac{120k^3}{15\sqrt7\,k^2}
\]
\[
R=\frac{8k}{\sqrt7}
\]
Step 5: Find the required ratio.
\[
\frac{R}{r}
=
\frac{\frac{8k}{\sqrt7}}
{\frac{\sqrt7}{2}k}
\]
\[
=\frac{16}{7}
\]
Therefore,
\[
R:r=16:7
\]
Step 6: Final conclusion.
Hence,
\[
\boxed{16:7}
\]