Concept:
For mixed partial derivative:
\[
\frac{\partial^2 z}{\partial x\partial y}
\]
we first differentiate with respect to \(x\), then differentiate the result with respect to \(y\).
Step 1: Given:
\[
z=x^2y^3+e^y\sin x
\]
Step 2: Differentiate with respect to \(x\).
\[
\frac{\partial z}{\partial x}
=
2xy^3+e^y\cos x
\]
Step 3: Now differentiate with respect to \(y\).
\[
\frac{\partial}{\partial y}\left(2xy^3+e^y\cos x\right)
\]
\[
=6xy^2+e^y\cos x
\]
Therefore,
\[
\boxed{6xy^2+e^y\cos x}
\]