Step 1: Understanding the Concept
Water-soluble hormones act on cell surface receptors, so the hormone is the first messenger.
Step 2: Second messengers
The binding creates small molecules inside the cell: cAMP, cGMP, \(\text{IP}_3\), \(\text{Ca}^{++}\) and DAG. They change cell activity.
Step 3: Eliminate
ATP, DNA and RNA are not messengers. ACTH, TSH and FSH are hormones. Adenylate cyclase, phospholipase C and protein kinase A are enzymes.
Step 4: Conclusion
The group of secondary messengers is cAMP, \(\text{Ca}^{++}\), cGMP and \(\text{IP}_3\).
Final Answer:
The secondary messengers are cAMP, Ca, cGMP and IP3.
\[ \boxed{\text{(B) }\text{cAMP, Ca}^{++}\text{, cGMP, IP}_{3}} \]