Question:
High serum triglycerides are seen in all of the following conditions EXCEPT:
High serum triglycerides are seen in all of the following conditions EXCEPT:
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Which lipid disorder cannot even export triglyceride from the liver/gut?
Updated On: Jun 25, 2026
- High fructose intake
- Diabetes mellitus
- Nephrotic syndrome
- Abetalipoproteinemia
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The Correct Option is D
Solution and Explanation
Step 1: Read the 'except' stem.
Three options raise triglycerides; one lowers them. Identify the outlier.
Step 2: Conditions that raise triglycerides.
High fructose drives hepatic de novo lipogenesis and VLDL output, raising TG. Diabetes mellitus (insulin deficiency/resistance) reduces lipoprotein lipase activity and increases VLDL, causing hypertriglyceridemia. Nephrotic syndrome increases hepatic lipoprotein synthesis (including VLDL) in response to hypoalbuminemia, raising both cholesterol and triglycerides.
Step 3: The exception.
Abetalipoproteinemia is caused by a defect in microsomal triglyceride transfer protein (MTP), so the liver and intestine cannot assemble apoB-containing lipoproteins (chylomicrons, VLDL, LDL). Triglycerides and cholesterol in plasma are therefore very LOW, not high. This is the exception.
Step 4: Conclusion.
Abetalipoproteinemia is the only listed condition associated with low, not high, triglycerides.
Key fact: MTP deficiency in abetalipoproteinemia blocks apoB lipoprotein assembly → absent chylomicrons/VLDL/LDL → low plasma TG.
Three options raise triglycerides; one lowers them. Identify the outlier.
Step 2: Conditions that raise triglycerides.
High fructose drives hepatic de novo lipogenesis and VLDL output, raising TG. Diabetes mellitus (insulin deficiency/resistance) reduces lipoprotein lipase activity and increases VLDL, causing hypertriglyceridemia. Nephrotic syndrome increases hepatic lipoprotein synthesis (including VLDL) in response to hypoalbuminemia, raising both cholesterol and triglycerides.
Step 3: The exception.
Abetalipoproteinemia is caused by a defect in microsomal triglyceride transfer protein (MTP), so the liver and intestine cannot assemble apoB-containing lipoproteins (chylomicrons, VLDL, LDL). Triglycerides and cholesterol in plasma are therefore very LOW, not high. This is the exception.
Step 4: Conclusion.
Abetalipoproteinemia is the only listed condition associated with low, not high, triglycerides.
Key fact: MTP deficiency in abetalipoproteinemia blocks apoB lipoprotein assembly → absent chylomicrons/VLDL/LDL → low plasma TG.
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