Question:
Given below are two statements:
Statement I: Reaginic antibodies (IgE) are usually get fixed to the mast cells.
Statement II: These antibodies are associated with the Type-I (anaphylactic) reaction in the body.
In light of the above statements, choose the correct answer from the options given below:
Given below are two statements:
Statement I: Reaginic antibodies (IgE) are usually get fixed to the mast cells.
Statement II: These antibodies are associated with the Type-I (anaphylactic) reaction in the body.
In light of the above statements, choose the correct answer from the options given below:
Statement I: Reaginic antibodies (IgE) are usually get fixed to the mast cells.
Statement II: These antibodies are associated with the Type-I (anaphylactic) reaction in the body.
In light of the above statements, choose the correct answer from the options given below:
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To remember this mechanism: IgE = Anaphylaxis/Type I = Mast Cell binding. The 'E' in IgE can be associated with 'Emergency' or immediate reactions.
Updated On: Aug 13, 2026
- Both Statement I and Statement II are true
- Both Statement I and Statement II are false
- Statement I is true but Statement II is false
- Statement I is false but Statement II is true
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Immunology classifies hypersensitivity reactions into four distinct types (Gell and Coombs classification) based on the immunological mediators involved and the timeline of the response.
Type I hypersensitivity, also known as immediate or anaphylactic hypersensitivity, is mediated by specific immunoglobulins and inflammatory cells.
Step 2: Detailed Explanation:
Let us analyze both statements in detail:
1. Statement I: Reaginic antibodies (IgE) are usually get fixed to the mast cells.
This statement is correct.
Reaginic antibodies, scientifically designated as Immunoglobulin E (IgE), are produced by plasma cells in response to specific allergens.
Once secreted, IgE molecules bind with high affinity to specialized $Fc\epsilon RI$ receptors located on the surface of tissue mast cells and circulating basophils.
This binding "sensitizes" these cells, preparing them for future exposure to the same allergen.
Therefore, Statement I is true.
2. Statement II: These antibodies are associated with the Type-I (anaphylactic) reaction in the body.
This statement is correct.
Type I hypersensitivity reactions are classic immediate allergic responses, ranging from mild localized reactions (such as urticaria or allergic rhinitis) to life-threatening systemic anaphylaxis.
Upon subsequent exposure to the allergen, the antigen cross-links the IgE antibodies bound to the mast cell surface.
This cross-linking triggers rapid degranulation, releasing pre-formed vasoactive mediators such as histamine, heparin, leukotrienes, and prostaglandins.
These mediators cause vasodilation, increased vascular permeability, and bronchoconstriction.
Therefore, Statement II is true.
Both statements are accurate and complement each other in explaining the mechanism of immediate hypersensitivity.
Step 3: Final Answer:
Both Statement I and Statement II are true because IgE antibodies bind to mast cells and mediate Type I immediate anaphylactic reactions.
Therefore, the correct option is (A).
Immunology classifies hypersensitivity reactions into four distinct types (Gell and Coombs classification) based on the immunological mediators involved and the timeline of the response.
Type I hypersensitivity, also known as immediate or anaphylactic hypersensitivity, is mediated by specific immunoglobulins and inflammatory cells.
Step 2: Detailed Explanation:
Let us analyze both statements in detail:
1. Statement I: Reaginic antibodies (IgE) are usually get fixed to the mast cells.
This statement is correct.
Reaginic antibodies, scientifically designated as Immunoglobulin E (IgE), are produced by plasma cells in response to specific allergens.
Once secreted, IgE molecules bind with high affinity to specialized $Fc\epsilon RI$ receptors located on the surface of tissue mast cells and circulating basophils.
This binding "sensitizes" these cells, preparing them for future exposure to the same allergen.
Therefore, Statement I is true.
2. Statement II: These antibodies are associated with the Type-I (anaphylactic) reaction in the body.
This statement is correct.
Type I hypersensitivity reactions are classic immediate allergic responses, ranging from mild localized reactions (such as urticaria or allergic rhinitis) to life-threatening systemic anaphylaxis.
Upon subsequent exposure to the allergen, the antigen cross-links the IgE antibodies bound to the mast cell surface.
This cross-linking triggers rapid degranulation, releasing pre-formed vasoactive mediators such as histamine, heparin, leukotrienes, and prostaglandins.
These mediators cause vasodilation, increased vascular permeability, and bronchoconstriction.
Therefore, Statement II is true.
Both statements are accurate and complement each other in explaining the mechanism of immediate hypersensitivity.
Step 3: Final Answer:
Both Statement I and Statement II are true because IgE antibodies bind to mast cells and mediate Type I immediate anaphylactic reactions.
Therefore, the correct option is (A).
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