Step 1: Concept
Many enzymes require non-protein components to become catalytically active.
Step 2: Meaning
The protein part alone is the apoenzyme, and the non-protein part is the cofactor/coenzyme.
Step 3: Analysis
A holoenzyme represents the complete, active system consisting of the apoenzyme bound to its necessary cofactors.
Step 4: Conclusion
The holoenzyme is considered the functional unit of the enzyme as it possesses full catalytic activity.
Final Answer: (D)