Step 1: Write the general equation of the circle.
Let the centre of the circle be
\[
(a,b).
\]
Since the radius is \(4\), the equation of the circle is
\[
(x-a)^2+(y-b)^2=16.
\]
The given points are of the form
\[
\left(x,\frac{1}{x}\right).
\]
So,
\[
y=\frac{1}{x}.
\]
Step 2: Substitute \(y=\frac{1}{x}\) in the circle equation.
Substituting,
\[
(x-a)^2+\left(\frac{1}{x}-b\right)^2=16.
\]
Expanding,
\[
x^2-2ax+a^2+\frac{1}{x^2}-\frac{2b}{x}+b^2=16.
\]
Step 3: Convert into a polynomial equation.
Multiplying throughout by \(x^2\), we get
\[
x^4-2ax^3+(a^2+b^2-16)x^2-2bx+1=0.
\]
The four different real non-zero numbers
\[
x_1,x_2,x_3,x_4
\]
are the four roots of this equation.
Step 4: Use product of roots.
For a fourth-degree equation
\[
Ax^4+Bx^3+Cx^2+Dx+E=0,
\]
the product of roots is
\[
\frac{E}{A}.
\]
Here,
\[
A=1
\]
and
\[
E=1.
\]
Therefore,
\[
x_1x_2x_3x_4=\frac{1}{1}=1.
\]
Step 5: Final conclusion.
Hence,
\[
\boxed{1}.
\]