Question

Enzyme regulation by feedback inhibition.
A. Reduced enzyme activity.
B. Accumulation of end product.
C. End product bind to allosteric site.
D. Decrease in intermediate formation.
Choose the correct answer from the options given below:

• A. A, B, C, D
• B. B, C, A, D
• C. B, D, C, A
• D. D, A, B, C

Hint:

Think of feedback inhibition as a thermostat. When the "heat" (end product) gets too high, it triggers the "sensor" (allosteric site) to turn off the "furnace" (enzyme), preventing waste and overproduction!

Answer 1

The Correct Option is B

Concept: Feedback inhibition is a cellular control mechanism in which an enzyme's activity is inhibited by the system's end product. This allows a cell to regulate how much of an end product is produced.

Step 1: Analyze the logical biological sequence.

• B (Accumulation of end product): As the metabolic pathway operates, the concentration of the final product increases until it reaches a threshold.
• C (End product bind to allosteric site): The excess end product molecules bind to a specific regulatory (allosteric) site on the first or an early enzyme of the pathway.
• A (Reduced enzyme activity): This binding changes the conformation of the enzyme, making it less effective at catalyzing its reaction.
• D (Decrease in intermediate formation): With the early enzyme inhibited, the production of all subsequent intermediates in the pathway drops, effectively shutting down production.

Step 2: Final Sequence.
The most accurate chronological order of the feedback inhibition process is B $\rightarrow$ C $\rightarrow$ A $\rightarrow$ D.