Step 1: Understanding DNA replication.
DNA replication is a semi-conservative process where new DNA strands are synthesized using parental strands as templates. It involves continuous and discontinuous synthesis depending on strand orientation.
Step 2: Leading and lagging strands.
The leading strand is synthesized continuously in the 5' to 3' direction. The lagging strand, however, is synthesized discontinuously in short segments due to opposite orientation.
Step 3: Formation of fragments.
On the lagging strand, DNA polymerase synthesizes short DNA segments that are later joined by DNA ligase. These short segments are known as Okazaki fragments.
Step 4: Molecular mechanism.
Each Okazaki fragment begins with an RNA primer and is later extended by DNA polymerase before being sealed together to form a continuous strand.
Step 5: Biological significance.
This discontinuous synthesis ensures accurate replication of both DNA strands despite antiparallel structure.
Step 6: Final conclusion.
Thus, the discontinuously synthesized fragments are called Okazaki fragments.