Question:
During ampoule sealing, nitrogen flushing is used
During ampoule sealing, nitrogen flushing is used
Show Hint
Nitrogen = Inert; No Oxygen = No Oxidation.
Updated On: May 15, 2026
- Sterilize the product
- Increase filling speed
- Reduce in oxidation
- Improve clarity
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Concept
Ampoules are small, sealed glass vials used to contain sterile parenteral solutions.
Step 2: Meaning
Many drugs are sensitive to oxygen and can degrade through oxidative pathways if air is left in the headspace.
Step 3: Analysis
Nitrogen is an inert gas. By flushing the ampoule with nitrogen before sealing, atmospheric oxygen is displaced.
Step 4: Conclusion
Nitrogen flushing is a protective measure to ensure the stability of oxygen-sensitive medications. Final Answer: (C)
Was this answer helpful?
0
0
Top GPAT Pharmaceutics Questions
- Which of the following is an example of a thermosetting plastic material?
- Which of the following vehicles (not required to be sterile, but must be pyrogen free) is intended to be used in the manufacture of injectable products to be sterilized after preparation?
A typical skin cream consisting of stearic acid, potassium hydroxide, glycerin, water, preservative and perfume, would be commonly known as:
- Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: The pressure filling method for filling pharmaceutical aerosol is usually preferred over cold filling method
Reason R: Because with pressure filling method high production speed can be achieved and less propellant is lost.
In light of the above statements, choose the correct answer from the options given below - Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: In the manufacturing of glycero‐gelatin suppositories, overfilling of mould is necessary.
Reason R: Glycero‐gelatin bases contract very little on cooling and the excess cannot be neatly removed.
In light of the above statements, choose the correct answer from the options given below
View More Questions
Top GPAT Parenteral - product requiring sterile packaging Questions
- Water for injection is prepared by using___distillation
- The general purpose sodalime glass is not a suitable material for fabricating the container for
- What type of glass is not used for parenteral preparation?
- Addtion of which of the following to a large volume parntral product is not advised
- Parenteral product must be:
View More Questions
Top GPAT Questions
- Match the symbols in the List I with the terms used in the List II of conductance measurements, and
List I
SymbolsList II
TermsA \(\Omega^{-1}\) I Specific conductance B \(∧\) II Electrical conductance C k III Specific resistance D \(\rho\) IV Equivalent conductance
Choose the correct answer from the options given below: - Cottrell’s method is used for the measurement of:
- Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and
List I
List II
A Constant heat (q = 0) I Isothermal B Reversible process at constant temperature (dT = 0) II Isometric C Constant volume (dV = 0) III Adiabatic D Constant pressure (dP = 0) IV Isobar
Choose the correct answer from the options given below: - Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:
- Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:
View More Questions