Question

Cystic fibrosis is caused due to:

• A. mutation in a gene encoding G protein
• B. deficiency of adenyl cyclase
• C. mutation in a gene encoding an ABC transporter
• D. over activation of the Ca++ ATPase pump

Hint:

CFTR = Chloride Channel = ABC Transporter.

Answer 1

The Correct Option is C

Step 1: Concept
Genetic disorders often stem from defects in specific membrane proteins.

Step 2: Meaning
The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) is a chloride channel.

Step 3: Analysis
Structurally, the CFTR protein belongs to the ATP-binding cassette (ABC) transporter superfamily. Mutations in this gene disrupt chloride ion transport across membranes.

Step 4: Conclusion
Thus, the underlying cause is a mutation in a gene encoding an ABC transporter. Final Answer: (C)