Question

Cyclosporin act as an immunosuppressant by:

• A. TNF-a neutralizer
• B. IL-2 Calcineurin inhibitor
• C. DNA Synthesis inhibitor
• D. Inhibition of B-lymphocyte

Hint:

Cyclosporine + Cyclophilin = No Calcineurin = No IL-2.

Answer 1

The Correct Option is B

Step 1: Concept
Cyclosporin is a powerful immunosuppressant used primarily in organ transplantation to prevent rejection.

Step 2: Meaning
Immunosuppressants work by dampening the immune response, often by targeting T-cell activation.

Step 3: Analysis
Cyclosporin binds to cyclophilin to form a complex that inhibits calcineurin. Calcineurin is a phosphatase required for the activation of NFAT (Nuclear Factor of Activated T-cells), which is essential for the transcription of Interleukin-2 (IL-2).

Step 4: Conclusion
By inhibiting calcineurin, Cyclosporin suppresses the production of IL-2 and subsequent T-cell proliferation. Final Answer: (B)