Question

The immuno suppressant action of cyclosporine is due to

• A. Interference with antigen recognition
• B. Inhibition of gene transcription of interleukins
• C. Blockade of tissue response to inflammatory
• D. Inhibition of cell wall synthesis

Answer 1

The Correct Option is B

The question asks about the mechanism by which cyclosporine exerts its immunosuppressant action. Let's analyze the options provided:

1. Interference with antigen recognition: Cyclosporine does not operate by interfering with antigen recognition. Antigen recognition primarily involves antigen-presenting cells and the initial immune response, which is not directly targeted by cyclosporine.
2. Inhibition of gene transcription of interleukins: Cyclosporine works by inhibiting calcineurin, leading to the decreased production of interleukin-2 (IL-2) and other cytokines. IL-2 gene transcription is crucial for T-cell activation and proliferation, and its suppression results in immunosuppressive effects. Therefore, this option correctly describes the action of cyclosporine.
3. Blockade of tissue response to inflammatory: Cyclosporine is not primarily known for blocking tissue response to inflammatory signals, but rather for affecting T-cell activity at the gene transcription level.
4. Inhibition of cell wall synthesis: This mechanism is typical for antibiotics targeting bacteria, not for immunosuppressants like cyclosporine.

Hence, the correct answer is that cyclosporine's immunosuppressant action is due to the inhibition of gene transcription of interleukins, specifically IL-2, which plays a pivotal role in T-cell activation.