Question:
Conversion of T4 to T3 inhibition is associated with
Conversion of T4 to T3 inhibition is associated with
Updated On: Feb 24, 2026
- Propylthiouracil
- Radioactive iodine
- Lugol's iodine
- Carbimazole
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
The question pertains to the pharmacological aspect of drugs that affect thyroid hormone levels. Specifically, it asks which substance is associated with the inhibition of the conversion of thyroxine (T4) to triiodothyronine (T3).
Let's analyze the options:
- Propylthiouracil: This drug is an antithyroid agent that works by inhibiting the enzyme thyroid peroxidase, as well as inhibiting the conversion of T4 to T3 peripherally. Therefore, Propylthiouracil is the correct answer since it directly inhibits T4 to T3 conversion.
- Radioactive iodine: It is used to destroy thyroid tissue by radiation to treat hyperthyroidism, but it does not directly inhibit the conversion of T4 to T3.
- Lugol's iodine: This is a strong iodine solution used in various medical applications, including reducing thyroid hormone secretion temporarily, but it does not inhibit the peripheral conversion of T4 to T3.
- Carbimazole: This is an antithyroid drug that is a precursor to methimazole in the body, which inhibits thyroid peroxidase but does not inhibit the conversion of T4 to T3.
After evaluating all the options, the successful inhibition of the conversion of T4 to T3 is uniquely performed by Propylthiouracil. Therefore, the correct answer is Propylthiouracil.
Was this answer helpful?
0
0
Top GPAT Pharmacology Questions
- Ethylketazocine is a 6,7‐benzomorphan derivative with _____ receptor selectivity.
- Which of the following is NOT a cause for the drug undergoing nonlinear pharmacokinetics
- Match List I with List II
List I-Drugs List II-Classes A Anakinra I IL‐2 receptor antagonist B Basiliximab II TNFα inhibitors C Infliximab III Calcineurin inhibitors D Tacrolimus IV mTOR inhibitors E - V IL‐1 receptor antagonist Choose the correct answer from the options given below:
- The ‘Up‐and‐Down’ method for a projected LD50 determination is described in the…..
- Match List I with List II
List I-(Poisoning) List II-(Treatment) A Warfarin I Pralidoxime B Carbon monoxide II Oxygen C Cyanide III Vitamin K D Nitrites IV Dicobalt edatate E Organophosphates V Methylene blue
Choose the correct answer from the options given below:
View More Questions
Top GPAT Pharmacology of Endocrine system Questions
- Which of the following is orally active testosterone derivative having progestational activity
- Which is NOT true about calcitriol?
- In respect of female reproductive cyck, which of the following statements are correct
1. The female reproductive cycle consists of menstrual phase, a pre-ovulatory phase, ovulation and a post ovulatory phase.
2. During the menstrual phase, small secondary follicles in the ovary begin to enlargewhile the uterus is shedding its lining
3. During the pre-ovulatory phase, a dominant follick continues to grow and begins tosecret estrogen and inhibin while the uterine lining begins to rebuild
4. Ovulation results in the release of an ovum and the shedding of the uterus lining tonourish and support
the release ovum
5. After ovulation, a corpus luteum forms the ruptured follicks and begins to secreteprogesterone and estrogen, which it will continue to do throughout pregnancy if the eggis fertilized
6. If pregnancy does not occur, then the corpus luteum degenerates into a scar knownas corpus albicans and uterine lining is prepared to be shed again - Antidiabetic action of gliburidestart at molecular level by which mechanism
- Insulin stimulates glucose transport by promoting the translocation of:
View More Questions
Top GPAT Questions
- Match the symbols in the List I with the terms used in the List II of conductance measurements, and
List I
SymbolsList II
TermsA \(\Omega^{-1}\) I Specific conductance B \(∧\) II Electrical conductance C k III Specific resistance D \(\rho\) IV Equivalent conductance
Choose the correct answer from the options given below: - Cottrell’s method is used for the measurement of:
- Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and
List I
List II
A Constant heat (q = 0) I Isothermal B Reversible process at constant temperature (dT = 0) II Isometric C Constant volume (dV = 0) III Adiabatic D Constant pressure (dP = 0) IV Isobar
Choose the correct answer from the options given below: - Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:
- Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:
View More Questions