Step 1: Concept
Molecular genetics, transcription, and translation processes.
Step 2: Analysis
* Statement A is correct: Transcription occurs in the 5' $\rightarrow$ 3' direction using the 3' $\rightarrow$ 5' strand as a template.
* Statement B is correct: Khorana's chemical method helped synthesize RNA homopolymers, essential for deciphering the genetic code.
* Statement C is incorrect: The amino acid acceptor end (CCA-OH) of tRNA attaches to the amino acid, while the anticodon loop contains bases complementary to the mRNA codon.
* Statement D is correct: 23S rRNA acts as a ribozyme (peptidyl transferase) in bacterial ribosomes.
Step 3: Conclusion
Statements A, B, and D are correct.
Final Answer: (D)