Question

Chlorpromazine acts centrally by blocking _____ receptors.

• A. Dopamine D2
• B. GABA-A
• C. Muscarinic
• D. AMDA

Hint:

Typical Antipsychotics = D2 Blockers.

Answer 1

The Correct Option is A

Step 1: Concept
Antipsychotic drugs (neuroleptics) are used to manage symptoms of schizophrenia and other psychoses.

Step 2: Meaning
The therapeutic effect of typical antipsychotics is linked to their action on the dopamine pathways in the brain.

Step 3: Analysis
Chlorpromazine is a typical antipsychotic of the phenothiazine class. It works primarily by antagonizing (blocking) post-synaptic Dopamine D2 receptors in the mesolimbic pathway.

Step 4: Conclusion
The central action of chlorpromazine is defined by the blockade of Dopamine D2 receptors.

Final Answer: (A)