Question

Arrange the following intermediates in the synthesis of isoprenoids in the right sequence
A. Squalence
B. Farnesyl PP
C. Geranyl PP 
D. Acetyl CoA
E. Mevalonate
Choose the correct answer from the options given below:

• A. D, B, C,A, E
• B. D, E, C, B, A
• C. B, C, D,A, E
• D. E, B, C, A, D

Answer 1

The Correct Option is B

The synthesis of isoprenoids, or terpenoids, is a significant biochemical process, involving several distinct intermediates. To organize these intermediates in the correct sequence, it's essential to understand the biosynthetic pathway of isoprenoid synthesis.

1. Acetyl CoA (D): The process begins with Acetyl CoA, a fundamental building block in numerous biochemical pathways, including the biosynthesis of isoprenoids.
2. Mevalonate (E): Acetyl CoA undergoes a series of enzymatic transformations to produce mevalonate. This conversion involves multiple steps such as the condensation of three Acetyl CoA molecules and subsequent reductions.
3. Geranyl PP (C): Mevalonate is further phosphorylated and decarboxylated to form isopentenyl pyrophosphate (IPP) and then converted to Geranyl pyrophosphate (GPP), a key intermediate.
4. Farnesyl PP (B): The successive addition of another IPP molecule to GPP results in the formation of Farnesyl pyrophosphate, which is a precursor to various important isoprenoids.
5. Squalene (A): Finally, two farnesyl pyrophosphate molecules condense to form Squalene. Squalene is a pivotal intermediate in the formation of more complex isoprenoids and sterols, such as cholesterol.

Based on the above pathway and following the intermediates in the correct order, the sequence is indeed:

Correct Sequence: D, E, C, B, A

This is reflected in the provided options, where the correct choice is:

Option: D, E, C, B, A