Question:
Amyloids- the insoluble fibrous aggregates deposited in certain tissues- which result in the development of fatal human diseases, can chemically be regarded as:
Amyloids- the insoluble fibrous aggregates deposited in certain tissues- which result in the development of fatal human diseases, can chemically be regarded as:
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Protein misfolding and amyloid aggregate formation are governed by thermodynamic stability, where the amyloid state often represents a highly stable, low-energy state of the polypeptide chain.
Updated On: Jul 13, 2026
- Resistant starch
- Prebiotics
- Glycolipids
- Misfolded proteins
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The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Proteins must fold into highly specific three-dimensional conformations to perform their biological functions. Misregulation of this process can result in aggregates that cause disease.
Step 2: Detailed Explanation:
Amyloids are highly organized, insoluble, thread-like fibrous aggregates.
They form when normally soluble proteins misfold and associate with one another.
These aggregates typically adopt a prominent cross-\(\beta\) sheet quaternary structure that is extremely resistant to proteolysis.
The progressive accumulation and deposition of amyloids in vital tissues lead to cellular dysfunction and organ damage, causing neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.
Step 3: Final Answer:
Chemically, amyloids are regarded as Misfolded proteins.
Proteins must fold into highly specific three-dimensional conformations to perform their biological functions. Misregulation of this process can result in aggregates that cause disease.
Step 2: Detailed Explanation:
Amyloids are highly organized, insoluble, thread-like fibrous aggregates.
They form when normally soluble proteins misfold and associate with one another.
These aggregates typically adopt a prominent cross-\(\beta\) sheet quaternary structure that is extremely resistant to proteolysis.
The progressive accumulation and deposition of amyloids in vital tissues lead to cellular dysfunction and organ damage, causing neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.
Step 3: Final Answer:
Chemically, amyloids are regarded as Misfolded proteins.
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