Question

Aminoglycoside antibiotics act by inhibiting

• A. Microtubule formation
• B. Dna replication
• C. Cell wall synthesis
• D. Protein synthesis

Hint:

Aminoglycosides = 30S Ribosome binding = Protein synthesis inhibition.

Answer 1

The Correct Option is D

Step 1: Concept
Aminoglycosides (like Streptomycin and Gentamicin) are bactericidal antibiotics used primarily against gram-negative bacteria.

Step 2: Meaning
Their mechanism involves interfering with the translation of genetic information into functional proteins.

Step 3: Analysis
Aminoglycosides bind irreversibly to the 30S ribosomal subunit. This binding causes misreading of t-RNA and inhibits the translocation of the peptide chain, effectively halting bacterial growth.

Step 4: Conclusion
Consequently, the primary mechanism of action for aminoglycosides is the inhibition of bacterial protein synthesis.

Final Answer: (D)