Question:
\(\alpha\)-Ketoglutarate and Oxaloacetate act as precursors in the synthesis of ______.
\(\alpha\)-Ketoglutarate and Oxaloacetate act as precursors in the synthesis of ______.
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Krebs cycle intermediates also supply carbon skeletons for amino acid synthesis.
Updated On: Nov 12, 2026
- Fatty acids, Malic acid
- Glutamic acid, Aspartic acid
- Succinic acid, Cholesterol
- Citric acid, Aconitic acid
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The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept
The Krebs cycle is amphibolic: it breaks down acetyl CoA and also supplies intermediates for biosynthesis.
Step 2: Amino acid formation
\(\alpha\)-Ketoglutarate (5C) takes up an amino group and becomes glutamic acid.\nOxaloacetate (4C) is transaminated to aspartic acid.
Step 3: Conclusion
So \(\alpha\)-ketoglutarate and oxaloacetate are precursors of glutamic acid and aspartic acid.
Final Answer:
The precursors lead to glutamic acid and aspartic acid. \[ \boxed{\text{(B) }\text{Glutamic acid, Aspartic acid}} \]
The Krebs cycle is amphibolic: it breaks down acetyl CoA and also supplies intermediates for biosynthesis.
Step 2: Amino acid formation
\(\alpha\)-Ketoglutarate (5C) takes up an amino group and becomes glutamic acid.\nOxaloacetate (4C) is transaminated to aspartic acid.
Step 3: Conclusion
So \(\alpha\)-ketoglutarate and oxaloacetate are precursors of glutamic acid and aspartic acid.
Final Answer:
The precursors lead to glutamic acid and aspartic acid. \[ \boxed{\text{(B) }\text{Glutamic acid, Aspartic acid}} \]
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