Aerobic dehydrogenase in biological oxidation contains:
Show Hint
- NAD
- NADH
- NADP
- FMN \& FAD
The Correct Option is D
Approach Solution - 1
Step 1: Role of aerobic dehydrogenases in biological oxidation. Aerobic dehydrogenases are enzymes that play a crucial role in biological oxidation by transferring electrons from substrates to the electron transport chain during aerobic respiration.
Step 2: Coenzymes associated with aerobic dehydrogenases. Aerobic dehydrogenases primarily use flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) as their coenzymes. These flavins are involved in redox reactions, acting as electron carriers.
Step 3: Why other options are incorrect. - (A) NAD: Nicotinamide adenine dinucleotide is used by other dehydrogenases, such as those in glycolysis and the Krebs cycle, but not predominantly in aerobic dehydrogenases.
- (B) NADH: Refers to the reduced form of NAD, a product of some metabolic pathways, not directly contained in aerobic dehydrogenases.
- (C) NADP: Nicotinamide adenine dinucleotide phosphate is used in anabolic pathways, not in aerobic dehydrogenation.
Approach Solution -2
The question asks which coenzyme is found in aerobic dehydrogenases, the class of enzymes that can pass electrons directly to molecular oxygen during biological oxidation. Checking what each listed molecule does in metabolism identifies the answer.
- NAD: Nicotinamide adenine dinucleotide is the coenzyme used by anaerobic dehydrogenases, the enzymes of glycolysis and the Krebs cycle that hand electrons to the electron transport chain rather than to oxygen directly.
- NADH: This is simply the reduced form of NAD produced after it accepts electrons during metabolism. It is a product of anaerobic dehydrogenase activity, not the coenzyme built into an aerobic dehydrogenase.
- NADP: Nicotinamide adenine dinucleotide phosphate mainly supplies reducing power for biosynthetic, anabolic reactions such as fatty acid and steroid synthesis. It is not the coenzyme associated with aerobic dehydrogenases.
- FMN & FAD: Flavin mononucleotide and flavin adenine dinucleotide are the flavoprotein coenzymes built into aerobic dehydrogenases. Because these flavins can be reoxidized directly by molecular oxygen, forming hydrogen peroxide, the enzymes that carry them are classed as aerobic.
Only the flavin coenzymes FMN and FAD give a dehydrogenase the ability to react with oxygen directly, which is what defines the aerobic subclass.
Therefore, the correct answer is FMN & FAD.
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