Question:
According to USP, the range of sparingly solubility required to dissolve 1 part of solute should be
According to USP, the range of sparingly solubility required to dissolve 1 part of solute should be
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Understanding solubility classification aids in selecting proper solvents and designing appropriate dosage forms.
Updated On: Jul 14, 2026
- 1 - 10
- 10 - 30
- 30 - 100
- 100 - 1000
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The Correct Option is C
Approach Solution - 1
Solubility is classified based on the amount of solvent required to dissolve one part of solute, often expressed as parts of solvent per part of solute. According to the United States Pharmacopeia (USP), the solubility ranges are categorized as follows:
- Very soluble: less than 1 part solvent required
- Freely soluble: 1 - 10 parts solvent
- Sparingly soluble: 30 - 100 parts solvent
- Slightly soluble: 100 - 1000 parts solvent
- Very slightly soluble: 1000 - 10,000 parts solvent
- Practically insoluble or insoluble: more than 10,000 parts solvent
Thus, the range for sparingly soluble substances corresponds to dissolving 1 part of solute in 30 to 100 parts of solvent. This classification is crucial for pharmaceutical formulation and drug delivery as it influences dissolution rate and bioavailability.
- Freely soluble: 1 - 10 parts solvent
- Sparingly soluble: 30 - 100 parts solvent
- Slightly soluble: 100 - 1000 parts solvent
- Very slightly soluble: 1000 - 10,000 parts solvent
- Practically insoluble or insoluble: more than 10,000 parts solvent
Thus, the range for sparingly soluble substances corresponds to dissolving 1 part of solute in 30 to 100 parts of solvent. This classification is crucial for pharmaceutical formulation and drug delivery as it influences dissolution rate and bioavailability.
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Approach Solution -2
The USP solubility classes rank substances by how many parts of solvent are needed to dissolve one part of solute. Working through the classes in order, from the most soluble to the least, quickly pins down where sparingly soluble falls.
- 1 - 10: Needing only 1 to 10 parts of solvent to dissolve one part of solute describes a substance that dissolves easily. USP labels this range freely soluble, a step above sparingly soluble, so this range is too small.
- 10 - 30: This range sits between freely soluble and sparingly soluble; USP assigns it to the soluble class. It still dissolves with a moderate amount of solvent, more easily than a sparingly soluble substance.
- 30 - 100: Needing 30 to 100 parts of solvent means the substance dissolves noticeably slower and needs a much larger volume of solvent than the soluble class above it, without being as poor as the slightly soluble class that follows. This is exactly the working definition USP gives for sparingly soluble.
- 100 - 1000: A substance needing this much solvent per part of solute is classed as slightly soluble, one step worse than sparingly soluble, so this range belongs to a different category altogether.
Reading down the solubility ladder, from freely soluble through soluble to sparingly soluble, shows the 30 - 100 parts range is the one USP reserves for sparingly soluble substances.
So the correct answer is 30 - 100.
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