Question:
A patient with hypoalbumina experience increased effect of highly protein bound drug because:
A patient with hypoalbumina experience increased effect of highly protein bound drug because:
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Only the "Free" drug does the "Work" (and causes side effects).
Updated On: May 15, 2026
- More of drug is present in active free form
- Renal excretion of the drug is blocked
- Drug distribution into tissues is increased
- Hepatic metabolism of the drug is increased
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Many drugs bind to plasma proteins like albumin. Only the "free" (unbound) fraction of the drug is pharmacologically active and able to interact with receptors.
Step 2: Meaning
Hypoalbuminemia is a condition characterized by low levels of albumin in the blood.
Step 3: Analysis
When albumin levels are low, there are fewer binding sites available for the drug. Consequently, a larger percentage of the drug remains unbound in the plasma.
Step 4: Conclusion
This increase in the concentration of the active free form leads to an enhanced therapeutic or toxic effect. Final Answer: (A)
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