To determine which drug binds the least to antivascular tissue, it's essential to understand the concept of drug distribution in the body. The binding of drugs to tissues, including vascular and non-vascular tissues, is influenced by several factors such as blood flow, tissue composition, and the physiochemical properties of the drug.
In this context, we are focusing on tissues such as the liver, muscle, lungs, and kidneys. The key is to identify tissues with less vascularity or lower capacity for drug binding.
Among the provided options:
The muscle tissue generally binds the least to antivascular tissues due to its lower blood flow compared to organs with a high metabolic rate and vascularity like the liver, lungs, and kidneys.
Therefore, the correct answer is:
| List I-Mechanism of action | List II-Drugs | ||
| A | DPP4 inhibitors | I | Metformin |
| B | KATP Channel blocker | II | Pioglitazone |
| C | PPAR activator | III | Glimepiride |
| D | AMP Activator | IV | Teneligliptin |
| E | - | V | α glucosidase inhibitors |
Choose the correct answer from the options given below:
| List I | List II | ||
| A | Phase‐I | I | Post marketing surveillance |
| B | Phase‐0 | II | Micro dosing |
| C | Phase‐3 | III | First in human dose |
| D | Phase‐4 | IV | Multicentric trials |
Choose the correct answer from the options given below:
| List I-Mechanism of action | List II-Drugs | ||
| A | DPP4 inhibitors | I | Metformin |
| B | KATP Channel blocker | II | Pioglitazone |
| C | PPAR activator | III | Glimepiride |
| D | AMP Activator | IV | Teneligliptin |
| E | - | V | α glucosidase inhibitors |
Choose the correct answer from the options given below:
List I | List II | ||
|---|---|---|---|
| A | \(\Omega^{-1}\) | I | Specific conductance |
| B | \(∧\) | II | Electrical conductance |
| C | k | III | Specific resistance |
| D | \(\rho\) | IV | Equivalent conductance |
List I | List II | ||
|---|---|---|---|
| A | Constant heat (q = 0) | I | Isothermal |
| B | Reversible process at constant temperature (dT = 0) | II | Isometric |
| C | Constant volume (dV = 0) | III | Adiabatic |
| D | Constant pressure (dP = 0) | IV | Isobar |