Question

A competitive benzodiazepine receptor antagonist is

• A. Flurazepam
• B. Carbamazepine
• C. Neostigmine
• D. Flumazenil

Hint:

Flumazenil "flushes" out the Benzodiazepines.

Answer 1

The Correct Option is D

Step 1: Concept
An antagonist binds to a receptor to block the action of an agonist without activating the receptor itself.

Step 2: Meaning
Benzodiazepine (BZD) receptor antagonists are used to reverse the sedative effects or toxicity of BZDs.

Step 3: Analysis
Flurazepam is a BZD agonist used for insomnia. Carbamazepine is an anticonvulsant and Neostigmine is a cholinergic drug. Flumazenil specifically and competitively blocks the BZD binding site on the GABA-A receptor.

Step 4: Conclusion
Flumazenil is the standard competitive antagonist for benzodiazepines.

Final Answer: (D)