Match the following
\[
\begin{array}{|c|l|c|l|}
\hline
& List-I & & List-II
\hline
A & \text{Apoenzyme} & I & \text{Non-protein part}
B & \text{Coenzyme} & II & \text{Protein part}
C & \text{Holoenzyme} & III & \text{Enzyme + cofactor}
D & \text{Active site} & IV & \text{Substrate-binding region}
\hline
\end{array}
\]
The correct answer is