Step 1: Understanding the Concept
Plasma contains proteins, regulators (hormones, enzymes), wastes and clotting-related substances.
Step 2: Check the first three
Prothrombin is a clotting factor, not an anticoagulant. Antibodies are for defence, not regulators. Heparin is an anticoagulant, not a waste.
Step 3: Check option D
Properdin is a plasma protein belonging to the defence (complement) system, along with albumin, globulin and fibrinogen. So this match is correct.
Final Answer:
The correct match is protein - properdin.
\[ \boxed{\text{(D) }\text{Protein - Properdin}} \]