Question:
Which serum marker appears after successful Hepatitis B vaccination?
Which serum marker appears after successful Hepatitis B vaccination?
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The vaccine carries only surface antigen, so the antibody formed is against it.
Updated On: Jun 24, 2026
- Anti-HBsAg
- Anti-HBeAg
- Anti-HBcAg
- HBsAg
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The Correct Option is A
Solution and Explanation
Step 1: The hepatitis B vaccine contains only the surface antigen (HBsAg) produced by recombinant technology. It does not contain the core or e antigens.
Step 2: After vaccination the body mounts an immune response only to the surface antigen, so the marker that appears is anti-HBs (antibody to HBsAg). A protective titre confirms successful immunization.
Step 3: Anti-HBc would appear only after natural infection because the core antigen is not part of the vaccine, so it helps distinguish vaccination from past infection. Anti-HBe also reflects infection rather than vaccination. HBsAg itself is a marker of active infection or carrier state, not of vaccine response.
Step 4: Therefore the serum marker after hepatitis B vaccination is anti-HBs (anti-HBsAg).
Step 2: After vaccination the body mounts an immune response only to the surface antigen, so the marker that appears is anti-HBs (antibody to HBsAg). A protective titre confirms successful immunization.
Step 3: Anti-HBc would appear only after natural infection because the core antigen is not part of the vaccine, so it helps distinguish vaccination from past infection. Anti-HBe also reflects infection rather than vaccination. HBsAg itself is a marker of active infection or carrier state, not of vaccine response.
Step 4: Therefore the serum marker after hepatitis B vaccination is anti-HBs (anti-HBsAg).
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