Question:
Which ring of warfarin is essential for its therapeutic activity:
Which ring of warfarin is essential for its therapeutic activity:
Updated On: Jul 14, 2026
- Purine
- Pyrimidine
- Lactone
- Coumarin
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The Correct Option is D
Approach Solution - 1
The correct option is (D): Coumarin.
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Approach Solution -2
The question asks which ring system in warfarin is essential for its blood-thinning activity. Let's look at each option.
- Purine: Purine is the double-ring system found in bases like adenine and guanine in DNA and RNA. It has no connection to warfarin's chemical structure.
- Pyrimidine: Pyrimidine is the single ring system found in bases like cytosine and thymine. This too is unrelated to warfarin, which is not built on a nucleic acid base.
- Lactone: A lactone is simply a general name for a cyclic ester, a functional group found in many natural products. Warfarin does contain a lactone-type ring as part of its structure, but this generic functional group alone does not explain why warfarin blocks blood clotting.
- Coumarin: Warfarin is built on a 4-hydroxycoumarin core. This specific bicyclic ring closely resembles the structure of vitamin K, which lets warfarin occupy and block the enzyme vitamin K epoxide reductase (VKORC1) that the body needs to activate clotting factors. This structural mimicry is what actually gives warfarin its anticoagulant effect.
While the coumarin ring technically contains a lactone, it is the specific coumarin scaffold and its resemblance to vitamin K, not the generic lactone functional group, that is essential for warfarin's therapeutic action.
Therefore, the correct answer is Coumarin.
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