Question:
Which prostaglandin analogue is used to keep the ductus arteriosus patent in patent ductus arteriosus (PDA)?
Which prostaglandin analogue is used to keep the ductus arteriosus patent in patent ductus arteriosus (PDA)?
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A PGE-1 analogue keeps the duct open; misoprostol and alprostadil are the examples.
Updated On: Jun 24, 2026
- Anaprostone
- Misoprostol
- Danaprostone
- PGE-2
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The Correct Option is B
Solution and Explanation
Step 1: In duct-dependent congenital heart disease the ductus arteriosus must be kept open until definitive treatment. This is achieved with prostaglandin E1 (PGE-1) analogues, which relax ductal smooth muscle and maintain patency.
Step 2: Among the options, misoprostol is a prostaglandin E1 analogue and is the agent used to keep the duct open, so option b is correct. Alprostadil is the other classic PGE-1 agent used for the same purpose.
Step 3: The opposite clinical goal, closure of a persistently patent duct in a preterm infant, is achieved with prostaglandin inhibitors such as indomethacin or ibuprofen, not with prostaglandin analogues.
Step 4: Anaprostone and danaprostone are not standard agents for this indication, and PGE-2 is not the analogue used to maintain ductal patency, so they are incorrect.
Step 2: Among the options, misoprostol is a prostaglandin E1 analogue and is the agent used to keep the duct open, so option b is correct. Alprostadil is the other classic PGE-1 agent used for the same purpose.
Step 3: The opposite clinical goal, closure of a persistently patent duct in a preterm infant, is achieved with prostaglandin inhibitors such as indomethacin or ibuprofen, not with prostaglandin analogues.
Step 4: Anaprostone and danaprostone are not standard agents for this indication, and PGE-2 is not the analogue used to maintain ductal patency, so they are incorrect.
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