Question:
Which one of the following statements is FALSE regarding vincristine?
Which one of the following statements is FALSE regarding vincristine?
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Pick the wrong claim; vincristine actually does cause hair loss.
Updated On: Jun 24, 2026
- It is an alkaloid
- Its use is associated with neurotoxicity
- It does not cause alopecia
- It is a useful drug for induction of remission in acute lymphoblastic leukaemia
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The Correct Option is C
Solution and Explanation
Step 1: This is a negative stem, so the correct choice is the statement that is untrue about vincristine. Vincristine is a vinca alkaloid that works by binding tubulin and blocking microtubule assembly, arresting mitosis.
Step 2: Statement a is true, vincristine is a plant alkaloid. Statement d is true, it is a standard agent for inducing remission in childhood acute lymphoblastic leukaemia (though it is not used for maintenance).
Step 3: Statement b is true, peripheral neuropathy is the dose limiting and most prominent toxicity of vincristine. Other effects include SIADH.
Step 4: Statement c claims it does not cause alopecia. In fact alopecia is one of its recognised adverse effects, so this statement is false and is therefore the answer.
Step 2: Statement a is true, vincristine is a plant alkaloid. Statement d is true, it is a standard agent for inducing remission in childhood acute lymphoblastic leukaemia (though it is not used for maintenance).
Step 3: Statement b is true, peripheral neuropathy is the dose limiting and most prominent toxicity of vincristine. Other effects include SIADH.
Step 4: Statement c claims it does not cause alopecia. In fact alopecia is one of its recognised adverse effects, so this statement is false and is therefore the answer.
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