Question:
Pulmonary toxicity is seen with?
Pulmonary toxicity is seen with?
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Which chemotherapy drug is famous for interstitial pneumonitis and pulmonary fibrosis?
Updated On: Jun 24, 2026
- Bleomycin
- Cisplatin
- Doxorubicin
- Actinomycin D
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The Correct Option is A
Solution and Explanation
Step 1: Recall organ-specific toxicities of anticancer drugs, as each agent has a classic dose-limiting toxicity.
Step 2: Bleomycin is the classic cause of pulmonary toxicity. It produces interstitial pneumonitis that can progress to pulmonary fibrosis, mediated by oxygen free radical generation in lung tissue, which has low levels of the inactivating enzyme bleomycin hydrolase. This makes option A correct.
Step 3: Compare the other options. Cisplatin is classically nephrotoxic and ototoxic. Doxorubicin (an anthracycline) is classically cardiotoxic, causing dilated cardiomyopathy. Actinomycin D causes myelosuppression and gastrointestinal toxicity.
Step 4: The agent most strongly linked to lung toxicity is bleomycin, so the correct answer is option A.
Step 2: Bleomycin is the classic cause of pulmonary toxicity. It produces interstitial pneumonitis that can progress to pulmonary fibrosis, mediated by oxygen free radical generation in lung tissue, which has low levels of the inactivating enzyme bleomycin hydrolase. This makes option A correct.
Step 3: Compare the other options. Cisplatin is classically nephrotoxic and ototoxic. Doxorubicin (an anthracycline) is classically cardiotoxic, causing dilated cardiomyopathy. Actinomycin D causes myelosuppression and gastrointestinal toxicity.
Step 4: The agent most strongly linked to lung toxicity is bleomycin, so the correct answer is option A.
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