Question

Which one of the following options correctly matches the cell types (Panel-1) with the organs in which they are primarily located (Panel-2)?

Panel-1	Panel-2
(p) Microglia	(i) Brain
(q) Mesangial cells	(ii) Kidney
(r) Microfold cells	(iii) Small intestine

• A. (p)-(i); (q)-(ii); (r)-(iii)
• B. (p)-(i); (q)-(iii); (r)-(ii)
• C. (p)-(ii); (q)-(i); (r)-(iii)
• D. (p)-(iii); (q)-(ii); (r)-(i)

Hint:

Match each specialised cell to the organ where it normally lives: an immune cell of the brain, a capillary-support cell of the kidney, and an antigen-sampling cell of the gut.

Answer 1

The Correct Option is A

Step 1: Recall where microglia live.
Microglia are the resident immune cells of the central nervous system.
They act as the brain's own housekeeping cells, clearing debris and pathogens inside brain tissue.
So microglia (p) map to the brain (i).

Step 2: Recall where mesangial cells live.
Mesangial cells sit between the capillary loops inside the kidney's glomerulus.
They support the capillary tuft and help control the filtration rate by contracting or relaxing.
So mesangial cells (q) map to the kidney (ii).

Step 3: Recall where microfold cells live.
Microfold cells (M cells) sit over the Peyer's patches in the wall of the small intestine.
They sample antigens from the gut lumen and pass them to immune cells below, starting the gut immune response.
So microfold cells (r) map to the small intestine (iii).

Step 4: Match with the given options.
The correct set is (p)-(i); (q)-(ii); (r)-(iii), which is option (A).
Option (B) swaps kidney and small intestine between mesangial and microfold cells, which is wrong.
Option (C) sends microglia to the kidney, which is wrong since microglia belong to the brain.
Option (D) reverses all three pairs, which is wrong.

Final Answer:
Option (A): (p)-(i); (q)-(ii); (r)-(iii). \[ \boxed{\text{(A)}} \]