Question:
Which one of the following is a function of PGI2 (prostacyclin)?
Which one of the following is a function of PGI2 (prostacyclin)?
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Prostacyclin opposes thromboxane and relaxes smooth muscle - more than one statement fits.
Updated On: Jun 23, 2026
- Inhibits platelet aggregation
- Is a vasodilator
- Is pyrogenic like PGE2
- All of the above
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The Correct Option is D
Solution and Explanation
Step 1: PGI2, also called prostacyclin, is produced mainly by vascular endothelial cells from arachidonic acid via the enzyme prostacyclin synthase. It acts on IP receptors and raises cyclic AMP.
Step 2: A key action is inhibition of platelet aggregation, so it opposes thromboxane A2 and keeps the vessel surface non-thrombogenic. This makes option (a) correct.
Step 3: PGI2 is also a potent vasodilator and bronchodilator, which is why it lowers blood pressure and is used in pulmonary hypertension. This makes option (b) correct.
Step 4: Like PGE2, prostacyclin is pyrogenic and can raise body temperature, so option (c) is also correct.
Step 5: Because all three statements are true, the single best answer is (d) All of the above. No individual option can be the lone answer.
Step 2: A key action is inhibition of platelet aggregation, so it opposes thromboxane A2 and keeps the vessel surface non-thrombogenic. This makes option (a) correct.
Step 3: PGI2 is also a potent vasodilator and bronchodilator, which is why it lowers blood pressure and is used in pulmonary hypertension. This makes option (b) correct.
Step 4: Like PGE2, prostacyclin is pyrogenic and can raise body temperature, so option (c) is also correct.
Step 5: Because all three statements are true, the single best answer is (d) All of the above. No individual option can be the lone answer.
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