Question:

Which one of the following codons will NOT pair with anticodon of t-RNA?

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Stop codons do not have tRNA; they are recognized by release factors.
Updated On: Feb 9, 2026
  • AUU
  • UAG
  • UUU
  • CUC
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The Correct Option is B

Solution and Explanation

Step 1: Understanding codon–anticodon pairing.
During translation, mRNA codons pair with complementary anticodons present on tRNA molecules to add specific amino acids to the growing polypeptide chain.
Step 2: Identifying stop codons.
Some codons do not code for any amino acid and hence do not have corresponding tRNA anticodons. These are called stop codons.
The three stop codons are UAA, UAG, and UGA.
Step 3: Analysis of options.
(A) AUU: Codes for isoleucine and pairs with tRNA.
(B) UAG: Correct — it is a stop codon and does not pair with any tRNA anticodon.
(C) UUU: Codes for phenylalanine and pairs with tRNA.
(D) CUC: Codes for leucine and pairs with tRNA.
Step 4: Conclusion.
The codon that does NOT pair with any tRNA anticodon is UAG.
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