Question

Which of the statements regarding the sequence of events from DNA to RNA to protein to enzyme (hexokinase) is correct? A. The linear sequence of deoxyribonucleotides in the DNA encoding hexokinase is transcribed into an RNA molecule with the complementary ribonucleotide sequence.
B. The RNA sequence is translated into the linear protein chain of hexokinase.
C. The linear sequence of deoxyribonucleotides in the DNA encodes for protein hexokinase.
D. The linear protein chain of hexokinase folds into its native three-dimensional shape, aided by molecular chaperones, to catalyze the phosphorylation of glucose using ATP as the phosphoryl group donor.

• A. A, B and D Only
• B. B, C and D Only
• C. C and D Only
• D. A and D Only

Hint:

Central Dogma: DNA $\to$ RNA $\to$ Protein $\to$ Enzyme. Think of it as “Blueprint $\to$ Message $\to$ Structure $\to$ Function.”

Answer 1

The Correct Option is A

Step 1: Concept
The central dogma of molecular biology describes the flow of genetic information: DNA $\to$ RNA $\to$ Protein $\to$ Functional Enzyme.

Step 2: Meaning
DNA provides the template, RNA acts as the messenger, proteins are synthesized, and enzymes are folded proteins with catalytic activity.

Step 3: Analysis
Statement A correctly describes transcription. Statement B correctly describes translation. Statement C is misleading because DNA does not directly encode proteins; it encodes RNA first. Statement D is correct, describing protein folding and enzyme function.

Step 4: Conclusion
The correct sequence is represented by A, B, and D.

Final Answer: (A)