Step 1: Understanding the Concept:
Stem cells are undifferentiated biological cells that can differentiate into specialized cells and divide through mitosis to produce more stem cells (self-renewal).
Step 2: Detailed Explanation:
- Statement A is correct: Embryonic stem cells (ESCs) are harvested from the inner cell mass of the blastocyst (an early stage of embryonic development).
- Statement B is correct: Isolated ESCs can be cultured and maintained indefinitely in an undifferentiated state in the laboratory under specific media conditions.
- Statement C is incorrect: Stem cells are unspecialized (undifferentiated) cells. They only become specialized cells (like muscle, nerve, or red blood cells) after undergoing differentiation.
- Statement D is correct: A defining property of stem cells is self-renewal, the ability to undergo numerous cycles of cell division while maintaining their undifferentiated state over long periods.
- Therefore, statements (A), (B), and (D) are correct.
Step 3: Final Answer:
The correct statements regarding stem cells are (A), (B), and (D) only.