Question:
Which of the following statements are correct about poly-A-tail addition to a pre-mRNA:
A. Polyadenylation signals in mammalian cells consist of the hexanucleotide AAUAAA in addition to upstream and downstream (U- or GU-rich) elements.
B. Polyadenylation signals consist of the hexanucleotide GGUAAA.
C. Poly-A polymerase adds a poly-A tail consisting of about 50 Adenines to the 3' end.
D. Poly-A polymerase adds a poly-A tail consisting of about 200 Adenines to the 3' end.
Which of the following statements are correct about poly-A-tail addition to a pre-mRNA:
A. Polyadenylation signals in mammalian cells consist of the hexanucleotide AAUAAA in addition to upstream and downstream (U- or GU-rich) elements.
B. Polyadenylation signals consist of the hexanucleotide GGUAAA.
C. Poly-A polymerase adds a poly-A tail consisting of about 50 Adenines to the 3' end.
D. Poly-A polymerase adds a poly-A tail consisting of about 200 Adenines to the 3' end.
B. Polyadenylation signals consist of the hexanucleotide GGUAAA.
C. Poly-A polymerase adds a poly-A tail consisting of about 50 Adenines to the 3' end.
D. Poly-A polymerase adds a poly-A tail consisting of about 200 Adenines to the 3' end.
Show Hint
AAUAAA is the signal. Think of âA lotâ of A's---roughly 200 of them.
Updated On: May 28, 2026
- B and C Only
- A and C Only
- D Only
- A and D Only
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The Correct Option is D
Solution and Explanation
Step 1--3: Analysis
Statement A is true (AAUAAA is the conserved consensus). Statement B is false. Statement C is false (the tail is much longer). Statement D is true: a typical poly-A tail is approximately 200--250 nucleotides long.
Step 4: Conclusion
A and D are correct.
Final Answer: (D)
Statement A is true (AAUAAA is the conserved consensus). Statement B is false. Statement C is false (the tail is much longer). Statement D is true: a typical poly-A tail is approximately 200--250 nucleotides long.
Step 4: Conclusion
A and D are correct.
Final Answer: (D)
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